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Dutch scientists have developed a fundamentally new approach to treatment of HIV infection using genetically modified blood stem cells, reports PhysOrg.

Currently, the most effective treatment for this infection is the reception combination antiviral drugs known as highly active antiretroviral therapy (HAART, HAART). These drugs do not destroy the virus, but only prevent its multiplication in the body, and upon their acceptance disease continues to evolve. Given that many patients for various reasons, interrupted treatment, and the fact that HIV is constantly changing, acquiring drug resistance, there is a need for alternative therapies.

Researchers from the University of Amsterdam developed a fundamentally new approach to treatment, which can provide long-term therapeutic effect after single medical intervention. He is in the delivery of antiviral genes in the DNA of immune cells, allowing them to independently resist the virus.

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To do this, from the bone marrow of the patient receiving an isolated culture of hematopoietic stem cells - the predecessors of lymphocytes. Under laboratory conditions, the DNA of these cells build in genes that encode small fragments of RNA complementary to key genes of HIV.

Then modified in such a way stem cells are introduced back into the patient, which are always new mature lymphocytes. After contact with HIV in lymphocytes such fragments of RNA associated with the corresponding genes of the virus, blocking them (a process known as RNA interference). Thus, production of new virus particles becomes impossible.

According to the author's development of Professor Ben Berkhauta (Ben Berkhout), preliminary research methodology gave encouraging results, and currently is testing its effectiveness and safety in laboratory animals. If successful, scientists expect to begin clinical trials of a new method of therapy of HIV infection, not later than three years.